|
KMID : 0613820220320070550
|
|
Journal of Life Science
2022 Volume.32 No. 7 p.550 ~ p.566
|
|
|
Protective Effects of Traditional Korean Medicine Preparations, Herbs, and Active Compounds on the Blood?brain Barrier in Ischemic Stroke Model
|
|
Shin Su-Bin
Jang Seok-Ju
Lee Na-Gyeong
Choi Byung-Tae
Shin Hwa-Kyoung
|
|
|
Abstract
|
|
|
|
Stroke is among the leading causes of death and long-term physical and cognitive disabilities worldwide, affecting an estimated 15 million people annually. The pathophysiological process of stroke is complicated by multiple and coordinated events. The breakdown of the blood?brain barrier (BBB) in people with stroke can significantly contribute to the development of ischemic brain injury. Therefore, BBB disruption is recognized as a hallmark of stroke; thus, it is important to develop novel therapeutic strategies that can protect against BBB dysfunction in ischemic stroke. Traditional medicines are composed of natural products, which represent a promising source of new ingredients for the development of conventional medicines. Indeed, several studies have shown the effectiveness of Korean medicine on stroke, highlighting the value of Korean medicinal treatment for ischemic stroke. This review summarizes the current information and underlying mechanisms regarding the ameliorating effects of the formula, decoction, herbs, and active components of traditional Korean medicine on cerebral ischemia-induced BBB disruption. These traditional medicines were shown to have protective effects on the BBB in many cellular and animal ischemia models of stroke, and experiments in various animal species, such as mice and rats. In addition, they showed brain-protective effects by protecting the BBB through the regulation of tight junction proteins and matrix metalloproteinase-9, reducing edema, neuroinflammation, and neuronal cell death. We hope that this review will help promote further investigation into the neuroprotective effects of traditional Korean medicines and stimulate the performance of clinical trials on Korean herbal medicine?derived drugs in patients with stroke.
|
|
|
KEYWORD
|
|
|
Blood-brain barrier, matrix metalloproteinase, stroke, tight junction protein, traditional Korean medicine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|